Variants of Concern – FAQ

Frequently Asked Questions

What is a Variant?

Variants are viruses that have changed or mutated. All viruses change and mutate over time; variants are common in viruses with quick mutation rates such as coronaviruses or influenza.

How do viruses mutate?

Viruses such as SARS-CoV-2, which causes COVID-19, make imperfect copies of themselves as they move from person to person or from an animal to a person. This leads to constant mutations and new variants. The term “variant” describes a version of the virus with a specific set of mutations.
Many mutations often don’t provide any advantage to the virus. But sometimes a mutation can make a virus more transmissible or change the severity of the disease the virus causes. When the same mutation emerges in multiple places it could indicate that these mutations provide some advantage for the virus—making it easier to spread or to evade antibodies, for example.

When does a Variant become a Variant of Concern?

Variants become variants of concern (VOCs) when the mutations or changes have clinical or public health significance. It is concerning when mutations cause variants to:

• Increase transmissibility (spread)
• Increase virulence (severity of disease)
• Decrease vaccine effectiveness
• Alter diagnostic testing

Together, these affect the public health and healthcare response to the virus and our community’s ability to prevent the spread.

What makes these variants “concerning”?

These variants are especially concerning because they have mutations which affect the spike protein on the virus. The spike protein is what allows the virus to attach to human cells but is also how our immune systems can recognize it. The COVID-19 vaccines work by teaching our immune systems to recognize this spike protein too.

What are the VOCs for SARS-Cov-2?

The World Health Organization is actively tracking all Variants of Concern. You can learn more about them here.

How might mutations affect the vaccines?

Vaccines teach our immune system to respond to a virus by recognizing some key sign of it. Mutations that affect the parts of the virus that the immune system recognizes could undermine a vaccine’s effectiveness.

Data is still being collected about vaccine efficacy but preliminary results are encouraging. While the VOCs may change the spike protein, early data is showing that the vaccine is helpful at reducing the burden of disease – severe outcomes such as hospitalizations and death.

What can you do?

Data is still being collected on VOCs to better understand just how different they are. Erring on the side of caution is always wise, but continuing to follow good public health safety measures will help reduce teh burden of circulating variants on our health-care system:

• Proper masking
• Physical distancing
• Washing your hands
• Staying home when you are sick
• Quarantining when returning from travel
• Getting vaccinated/boosted when you can